Please visit the Instructions for Authors page before submitting a manuscript. Pathogens is an international peer-reviewed open access monthly journal published by MDPI. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. All manuscripts are thoroughly refereed through a single-blind peer-review process. Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website. Research articles, review articles as well as short communications are invited. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. All submissions that pass pre-check are peer-reviewed. Manuscripts can be submitted until the deadline. Once you are registered, click here to go to the submission form. Manuscripts should be submitted online at by registering and logging in to this website. We invite authors to submit research papers on this topic, with particular attention to genomic characteristics, pathogenesis, epidemiology, diagnosis, cross reactivity with other herpesviruses, immune response, and vaccination.įurthermore, considering CpHV.1 infection similar to human genital infection, fellow researchers are invited to consider the goat as a valid animal model for the development of valid vaccines and antiviral substances. This Special Issue of Pathogens will have to provide an overview of the latest advances in the study of CpHV-1 infection. Further studies to evaluate other serological cross reactivities with other alphaherpesviruses are welcome. This homology is responsible for a unidirectional serological cross-reactivity between BoHV-1and CpHV-1.
Further investigations are needed to assess if latent infection also occurs in heterologous hosts.ĬpHV-1 has a strong biological similarity to the human genital herpes virus (Herpes Simplex-2 (HVV-2)), responsible for herpetic genital infection in humans this has allowed us to hypothesize the use of a goat model for the development of antiviral drugs and vaccines against human herpetic infections.ĬpHV-1 has a homology between 50% and 80% in the nucleotide sequence with Bovine alphaherpesvirus 1 (BoHV-1). Like other alphaherpesviruses, CpHV-1 has the ability to latentize in the nerve ganglia of caprine species, and is reactivated experimentally by administering immunosuppressive drugs at high doses, while in the course of natural infection, reactivation and subsequent viral excretion is observed during estrus.Ĭross-species CpHV-1 infections have been documented repeatedly for ruminants alphaherpesviruses, a group of closely related viruses.
Vertical transmission occurs with abortion, and identification of the virus in organs of aborted fetuses causes relevant economic losses in breeding. In adult goats, it is possible to observe edema, erythema, erosions, and ulcers on the vulvovaginal mucosa, while in bucks, balanoposthitis is observed with hyperemia and ulcers. Caprine alphaherpesvirus 1 (CpHV-1) infection is responsible for systemic pathology in kids, and affects the genital tract of the adults, mainly through subacute infections.
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